Application of Orthobiologics in Achilles Tendinopathy: A Review.

Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically. We explain the concepts and definitions of each orthobiologic and the literature regarding its use in tendon disorders. The biological potential of these materials can be harnessed and administered into injured tissues, particularly in areas where standard healing is disrupted, a typical feature of Achilles tendinopathy. These products contain a wide variety of cell populations, cytokines, and growth factors, which have been shown to modulate many other cells at local and distal sites in the body. Collectively, they can shift the state of escalated inflammation and degeneration to reestablish tissue homeostasis. The typical features of Achilles tendinopathy are failed healing responses, persistent inflammation, and predominant catabolic reactions. Therefore, the application of orthobiologic tools represents a viable solution, considering their demonstrated efficacy, safety, and relatively easy manipulation. Perhaps a synergistic approach regarding the combination of these orthobiologics may promote more significant clinical outcomes rather than individual application. Although numerous optimistic results have been registered in the literature, additional studies and clinical trials are still highly desired to further illuminate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.

Perfuraçöes X abrasäo do osso subcondral no tratamento das lesöes condrais do joelho por via artroscópica / Perforations X abrasion of subchondral bone in the treatment of chondral lesions of the knee by arthroscopic way

Estudo prospectivo e comparativo entre as técnicas de perfuraçäo do osso subcondral e artroplastia por abrasäo das lesöes condrais do joelho foi realizado de forma aleatória em dois grupos de dez pacientes cada um. Ambas as técnicas foram realizadas por via videoartroscópica, sendo que em sete pacientes o resultado do tratamento inicial foi reavaliado aos seis meses de pós-operatório através de uma segunda artroscopia. O resultado comparativo baseou-se na resposta clínica ao tratamento estabelecido, sendo que o número de resultados insatisfatórios foi igual em ambos os grupos, sem que se pudesse verificar a supremacia de uma técnica sobre a outra

Alteraçöes cardiológicas subclínicas em pacientes com cirrose alcoólica / Subclinic myocardial abnormalities in patients with alcoholic cirrhosis

Foram estudados, quanto a alteraçöes subclínicas presentes em ecocardiograma uni-bidimensional com doppler-fluxo a cores, 20 pacientes portadores de cirrose alcoólica sem manifestaçöes clínicas, radiológicas e eletrocardiográficas de cardiopatia e comparados a um grupo controle com as mesmas características e sem doença hepática. Os achados ecocardiográficos dos dois grupos foram semelhantes, levando à conclusäo de que, näo havendo sinais evidentes de comprometimento cardíaco, säo improváveis achados ecocardiográficos subclínicos indicativos de miocardiopatia nos pacientes portadores de cirrose alcoólica